Hydrochloric Acid → 2-Chloro-5-piperazin-1-ylmethyl-N-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-benzamide, hydrochloride salt

HRID 2298057Notes

Reaction equation

HRID 2298057 reaction equation
[Cl:1][C:2]1[CH:21]=[CH:20][C:19]([CH2:22][N:23]2[CH2:28][CH2:27][N:26](C(OC(C)(C)C)=O)[CH2:25][CH2:24]2)=[CH:18][C:3]=1[C:4]([NH:6][CH2:7][C:8]12[CH2:17][CH:12]3[CH2:13][CH:14]([CH2:16][CH:10]([CH2:11]3)[CH2:9]1)[CH2:15]2)=[O:5].Cl>CO.O1CCOCC1>[ClH:1].[Cl:1][C:2]1[CH:21]=[CH:20][C:19]([CH2:22][N:23]2[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]2)=[CH:18][C:3]=1[C:4]([NH:6][CH2:7][C:8]12[CH2:9][CH:10]3[CH2:16][CH:14]([CH2:13][CH:12]([CH2:11]3)[CH2:17]1)[CH2:15]2)=[O:5]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 183815512-Chloro-5-(4-[{1,1-dimethylethyl}oxycarbonyl]-piperazin-1-yl)methyl-N-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-benzamide

Product 1

HCID 1317236792-Chloro-5-piperazin-1-ylmethyl-N-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-benzamide, hydrochloride salt

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

2-Chloro-5-(4-[{1,1-dimethylethyl}oxycarbonyl]-piperazin-1-yl)methyl-N-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-benzamide, (Example 8c, 0.080 g) was dissolved in methanol (3 ml), 4N HCl in dioxane (1 ml) was added and the mixture stirred at room temperature for 1.5 h. The solvent was removed under vacuum and the resulting solid was triturated with ether to afford the title compound as a white powder (0.062 g).

Workup

  1. customThe solvent was removed under vacuum
  2. customthe resulting solid was triturated with ether

Sources & evidence

ORD record
ord-003652588405443f8f81c8777a03592a
Source dataset
uspto-grants-2002_12
Patent number
US06492355B1

Reaction notes

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