Hydrochloric Acid → HCID 131723680, compound

HRID 2298060Notes

Reaction equation

HRID 2298060 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][N:9]2[CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]2)=[CH:4][C:3]=1[C:22]([NH:24][CH2:25][CH2:26][C:27]12[CH2:36][CH:31]3[CH2:32][CH:33]([CH2:35][CH:29]([CH2:30]3)[CH2:28]1)[CH2:34]2)=[O:23].Cl>CO.O1CCOCC1>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)=[CH:4][C:3]=1[C:22]([NH:24][CH2:25][CH2:26][C:27]12[CH2:28][CH:29]3[CH2:30][CH:31]([CH2:32][CH:33]([CH2:35]3)[CH2:34]1)[CH2:36]2)=[O:23]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 86758646HCID 86758646, compound

Product 1

HCID 131723680HCID 131723680, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

4-[[4-chloro-3-[[(2-tricyclo[3.3.1.13,7]dec-1-ylethyl)amino]carbonyl]phenyl]methyl]-1-piperazinecarboxylic acid, 1,1-dimethylethyl ester, (Example 18b, 0.270 g) was dissolved in methanol (3 ml), 4N HCl in dioxane (2 ml) was added and the mixture stirred for 14 h at room temperature. The solvent was removed under vacuum and the resulting solid was triturated with ether to afford the title compound as a white powder (0.207 g).

Workup

  1. customThe solvent was removed under vacuum
  2. customthe resulting solid was triturated with ether

Sources & evidence

ORD record
ord-c9b39572d3e74d9f81cffe2828395ff9
Source dataset
uspto-grants-2002_12
Patent number
US06492355B1

Reaction notes

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