Hydrochloric Acid → HCID 131723681, compound

HRID 2298064Notes

Reaction equation

HRID 2298064 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][NH:9][CH:10]2[CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12][CH2:11]2)=[CH:4][C:3]=1[C:23]([NH:25][CH2:26][C:27]12[CH2:36][CH:31]3[CH2:32][CH:33]([CH2:35][CH:29]([CH2:30]3)[CH2:28]1)[CH2:34]2)=[O:24].CO.[ClH:39]>O1CCOCC1>[ClH:1].[ClH:39].[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][NH:9][CH:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)=[CH:4][C:3]=1[C:23]([NH:25][CH2:26][C:27]12[CH2:28][CH:29]3[CH2:30][CH:31]([CH2:32][CH:33]([CH2:35]3)[CH2:34]1)[CH2:36]2)=[O:24]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 56999879HCID 56999879, compound

Product 1

HCID 131723681HCID 131723681, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Prepared from 4-[[[4chloro-3-[[(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]carbonyl]phenyl]methyl]amino]-1-piperidinecarboxylic acid, 1,1-dimethylethyl ester (0.158 g, Example 31b) methanol (3 ml) and 4N hydrochloric acid solution in dioxane (2 ml). Solvents were removed under reduced pressure and the residue was triturated with ethyl acetate, iso-hexane and diethyl ether to give the title compound as a white solid (0.126 g).

Workup

  1. customSolvents were removed under reduced pressure
  2. customthe residue was triturated with ethyl acetate, iso-hexane and diethyl ether

Sources & evidence

ORD record
ord-18a00368b9db428c862562807bb44e11
Source dataset
uspto-grants-2002_12
Patent number
US06492355B1

Reaction notes

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