Hydrochloric Acid → HCID 131723682, compound

HRID 2298066Notes

Reaction equation

HRID 2298066 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][NH:9][CH:10]2[CH2:15][CH2:14][CH:13]([CH2:16][NH:17]C(=O)OC(C)(C)C)[CH2:12][CH2:11]2)=[CH:4][C:3]=1[C:25]([NH:27][CH2:28][C:29]12[CH2:38][CH:33]3[CH2:34][CH:35]([CH2:37][CH:31]([CH2:32]3)[CH2:30]1)[CH2:36]2)=[O:26].CO.[ClH:41]>O1CCOCC1>[ClH:1].[ClH:41].[NH2:17][CH2:16][CH:13]1[CH2:14][CH2:15][CH:10]([NH:9][CH2:8][C:5]2[CH:6]=[CH:7][C:2]([Cl:1])=[C:3]([CH:4]=2)[C:25]([NH:27][CH2:28][C:29]23[CH2:36][CH:35]4[CH2:34][CH:33]([CH2:32][CH:31]([CH2:37]4)[CH2:30]2)[CH2:38]3)=[O:26])[CH2:11][CH2:12]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 57204187HCID 57204187, compound

Product 1

HCID 131723682HCID 131723682, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Prepared from [[4-[[[4chloro-3-[[(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]carbonyl]phenyl]methyl]amino]cyclohexyl]methyl]-carbamic acid, 1,1-dimethylethyl ester (0.26 g, Example 32a) methanol (5 ml) and 4N hydrochloric acid solution in dioxane (2 ml). Solvents were removed under reduced pressure and the residue was triturated with diethyl ether to give the title compound as a white powder (0.191 g).

Workup

  1. customSolvents were removed under reduced pressure
  2. customthe residue was triturated with diethyl ether

Sources & evidence

ORD record
ord-06830cae29174c389c5c0a3600a31902
Source dataset
uspto-grants-2002_12
Patent number
US06492355B1

Reaction notes

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