Hydrochloric Acid → HCID 131723683, compound

HRID 2298068Notes

Reaction equation

HRID 2298068 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][NH:9][CH:10]2[CH2:15][CH2:14][CH:13]([NH:16]C(=O)OC(C)(C)C)[CH2:12][CH2:11]2)=[CH:4][C:3]=1[C:24]([NH:26][CH2:27][C:28]12[CH2:37][CH:32]3[CH2:33][CH:34]([CH2:36][CH:30]([CH2:31]3)[CH2:29]1)[CH2:35]2)=[O:25].CO.[ClH:40]>O1CCOCC1>[ClH:1].[ClH:40].[NH2:16][CH:13]1[CH2:12][CH2:11][CH:10]([NH:9][CH2:8][C:5]2[CH:6]=[CH:7][C:2]([Cl:1])=[C:3]([CH:4]=2)[C:24]([NH:26][CH2:27][C:28]23[CH2:29][CH:30]4[CH2:36][CH:34]([CH2:33][CH:32]([CH2:31]4)[CH2:37]2)[CH2:35]3)=[O:25])[CH2:15][CH2:14]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 86758647HCID 86758647, compound

Product 1

HCID 131723683HCID 131723683, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Prepared from [4-[[[4-chloro-3-[[(tricyclo[3.3.1.1 3,7]dec-1-ylmethyl)amino]carbonyl]phenyl]methyl]amino]cyclohexyl]-carbamic acid, 1,1-dimethylethyl ester (0.26 g, Example 33a), methanol (5 ml) and 4N hydrochloric acid solution in dioxane (1 ml). Solvents were removed under reduced pressure and the residue was triturated with diethyl ether to give the title compound as a white powder (0.190 g).

Workup

  1. customSolvents were removed under reduced pressure
  2. customthe residue was triturated with diethyl ether

Sources & evidence

ORD record
ord-9b87e53f70a14fff94bd194c2085461a
Source dataset
uspto-grants-2002_12
Patent number
US06492355B1

Reaction notes

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