Hydrochloric Acid → HCID 131723684, compound

HRID 2298072Notes

Reaction equation

HRID 2298072 reaction equation
C(OC(=O)[NH:7][CH:8]1[CH2:12][CH2:11][N:10]([C:13]2[CH:18]=[CH:17][C:16]([NH:19][C:20](=[O:32])[CH2:21][C:22]34[CH2:31][CH:26]5[CH2:27][CH:28]([CH2:30][CH:24]([CH2:25]5)[CH2:23]3)[CH2:29]4)=[C:15]([CH3:33])[CH:14]=2)[CH2:9]1)(C)(C)C.[ClH:35]>CO.O1CCOCC1>[ClH:35].[ClH:35].[NH2:7][CH:8]1[CH2:12][CH2:11][N:10]([C:13]2[CH:18]=[CH:17][C:16]([NH:19][C:20](=[O:32])[CH2:21][C:22]34[CH2:23][CH:24]5[CH2:30][CH:28]([CH2:27][CH:26]([CH2:25]5)[CH2:31]3)[CH2:29]4)=[C:15]([CH3:33])[CH:14]=2)[CH2:9]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 70157682HCID 70157682, compound

Product 1

HCID 131723684HCID 131723684, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

{1-[4-(2-(tricyclo[3.3.1.13,7]dec-1-yl)acetylamino)-3-methylphenyl]-pyrrolidin-3-yl}-carbamic acid tert-butyl ester (0.20 g, Example 35c) was dissolved in methanol (5 ml) and hydrochloric acid (0.5 ml of a 4N solution in dioxane) was added. After stirring at room temperature for 14 h, the mixture was evaporated to 2/3 original volume under reduced pressure. Diethyl ether was gradually added to the solution and the resulting precipitate collected by filtration, washed with diethyl ether and dried in vacuo to afford the title compound as a solid (0.15 g)

Workup

  1. customthe mixture was evaporated to 2/3 original volume under reduced pressure
  2. additionDiethyl ether was gradually added to the solution
  3. filtrationthe resulting precipitate collected by filtration
  4. washwashed with diethyl ether
  5. customdried in vacuo

Sources & evidence

ORD record
ord-8ad19f6bdcd04225960e056429f92529
Source dataset
uspto-grants-2002_12
Patent number
US06492355B1

Reaction notes

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