反应详情

4-(3-Methyl-4-nitrophenyl)piperazine-1-carboxylic acid tert-butyl ester (2 g, Example 36a), iron powder (1.74 g), ammonium chloride (1.67 g), ethanol (50 ml) and water (50 ml) were refluxed together under nitrogen for 2 h. The mixture was cooled and the iron was filtered off. Water (200 ml) was added to the residue and the product extracted into ethyl acetate (3×200 ml), dried (MgSO4), and concentrated to give the subtitle compound (1.22 g).

1. temperatureThe mixture was cooled
2. filtrationthe iron was filtered off
3. additionWater (200 ml) was added to the residue
4. extractionthe product extracted into ethyl acetate (3×200 ml)
5. dry with materialdried (MgSO4)
6. concentrationconcentrated