Hydrochloric Acid → HCID 131723685, compound

HRID 2298075Notes

Reaction equation

HRID 2298075 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17]([NH:20][C:21](=[O:33])[CH2:22][C:23]34[CH2:32][CH:27]5[CH2:28][CH:29]([CH2:31][CH:25]([CH2:26]5)[CH2:24]3)[CH2:30]4)=[C:16]([CH3:34])[CH:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:35]>CO.O1CCOCC1>[ClH:35].[ClH:35].[CH3:34][C:16]1[CH:15]=[C:14]([N:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[CH:19]=[CH:18][C:17]=1[NH:20][C:21](=[O:33])[CH2:22][C:23]12[CH2:30][CH:29]3[CH2:31][CH:25]([CH2:26][CH:27]([CH2:28]3)[CH2:32]1)[CH2:24]2

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 54016026HCID 54016026, compound

Product 1

HCID 131723685HCID 131723685, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

4-[4-(2-(tricyclo[3.3.1.13,7]dec-1-yl)acetylamino)-3-methylphenyl]-piperazine-1-carboxylic acid tert-butyl ester (0.05 g, Example 36c) was dissolved in methanol (2 ml) and hydrochloric acid (0.5 ml of a 4N solution in dioxane) was added. After stirring at room temperature for 14 h, the mixture was evaporated to 2/3 original volume under reduced pressure. Diethyl ether was gradually added to the solution and the resulting precipitate collected by filtration, washed with diethyl ether and dried in vacuo to afford the title compound as a solid (0.043 g)

Workup

  1. customthe mixture was evaporated to 2/3 original volume under reduced pressure
  2. additionDiethyl ether was gradually added to the solution
  3. filtrationthe resulting precipitate collected by filtration
  4. washwashed with diethyl ether
  5. customdried in vacuo

Sources & evidence

ORD record
ord-dd3f69e8eb88461a80612707374d44ee
Source dataset
uspto-grants-2002_12
Patent number
US06492355B1

Reaction notes

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