HCID 131723690, compound → HCID 131723689, compound

Participants

Reaction Steps

A solutuion of 2-chloro-5-(4-hydroxy-piperidin-4-yl)-N-(tricyclo[3.3.1.133,7]dec-1-ylmethyl)-benzamide, hydrochloride salt (0.25 g, Example 52) in concentrated hydrochloric acid (10 mn) was heated at 100° C. for 5 h. The solution was allowed to cool slowly. Colourless crystals separated. These were removed by filtration, washed with diethyl ether then acetonitrile and dried to afford the title compound (0.031 g).

Provenance & Evidence