HCID 131723690, compound → HCID 131723689, compound

HRID 2298083Notes

Reaction equation

HRID 2298083 reaction equation
Cl.[Cl:2][C:3]1[CH:22]=[CH:21][C:20]([C:23]2(O)[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]2)=[CH:19][C:4]=1[C:5]([NH:7][CH2:8][C:9]12[CH2:18][CH:13]3[CH2:14][CH:15]([CH2:17][CH:11]([CH2:12]3)[CH2:10]1)[CH2:16]2)=[O:6]>Cl>[ClH:2].[Cl:2][C:3]1[CH:22]=[CH:21][C:20]([C:23]2[CH2:28][CH2:27][NH:26][CH2:25][CH:24]=2)=[CH:19][C:4]=1[C:5]([NH:7][CH2:8][C:9]12[CH2:10][CH:11]3[CH2:17][CH:15]([CH2:14][CH:13]([CH2:12]3)[CH2:18]1)[CH2:16]2)=[O:6]

Participants

3

Reactant 1

HCID 131723690HCID 131723690, compound

Product 1

HCID 131723689HCID 131723689, compoundYield 25.9%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solutuion of 2-chloro-5-(4-hydroxy-piperidin-4-yl)-N-(tricyclo[3.3.1.133,7]dec-1-ylmethyl)-benzamide, hydrochloride salt (0.25 g, Example 52) in concentrated hydrochloric acid (10 mn) was heated at 100° C. for 5 h. The solution was allowed to cool slowly. Colourless crystals separated. These were removed by filtration, washed with diethyl ether then acetonitrile and dried to afford the title compound (0.031 g).

Workup

  1. temperatureto cool slowly
  2. customColourless crystals separated
  3. customThese were removed by filtration
  4. washwashed with diethyl ether
  5. dry with materialacetonitrile and dried

Sources & evidence

ORD record
ord-5adf6aae3e904ef2b9f00e9b7ef8ae79
Source dataset
uspto-grants-2002_12
Patent number
US06492355B1

Reaction notes

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