Hydrochloric Acid → HCID 131723692, compound

HRID 2298087Notes

Reaction equation

HRID 2298087 reaction equation
Cl.[Cl:2][C:3]1[CH:22]=[CH:21][C:20]([S:23][CH2:24][C:25]2(C(OC(C)(C)C)=O)[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)=[CH:19][C:4]=1[C:5]([NH:7][CH2:8][C:9]12[CH2:18][CH:13]3[CH2:14][CH:15]([CH2:17][CH:11]([CH2:12]3)[CH2:10]1)[CH2:16]2)=[O:6]>CO>[ClH:2].[Cl:2][C:3]1[CH:22]=[CH:21][C:20]([S:23][CH2:24][CH:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)=[CH:19][C:4]=1[C:5]([NH:7][CH2:8][C:9]12[CH2:10][CH:11]3[CH2:12][CH:13]([CH2:14][CH:15]([CH2:17]3)[CH2:16]1)[CH2:18]2)=[O:6]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18381557HCID 18381557, compound

Product 1

HCID 131723692HCID 131723692, compoundYield 193.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Hydrochloric acid (4N dioxane, 0.5 ml) was added to a solution of 2-chloro-5-(4-[{1,1-dimethylethyl}oxycarbonyl]piperidin-4-ylmethylsulfanyl)-N-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-benzamide (0.235 g, Example 58a) in methanol (10 ml). After 24 h the reaction mixture was concentrated, then triturated with ether to give the title compound (0.20 g).

Workup

  1. concentrationAfter 24 h the reaction mixture was concentrated
  2. customtriturated with ether

Sources & evidence

ORD record
ord-7b17d9b1ed2c4e00920bf1c4562c8f33
Source dataset
uspto-grants-2002_12
Patent number
US06492355B1

Reaction notes

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