Hydrochloric Acid → HCID 131723695, compound

HRID 2298092Notes

Reaction equation

HRID 2298092 reaction equation
[Br:1][C:2]1[CH:21]=[CH:20][C:19]([CH2:22][N:23]2[CH2:28][CH2:27][N:26](C(OC(C)(C)C)=O)[CH2:25][CH2:24]2)=[CH:18][C:3]=1[C:4]([NH:6][CH2:7][C:8]12[CH2:17][CH:12]3[CH2:13][CH:14]([CH2:16][CH:10]([CH2:11]3)[CH2:9]1)[CH2:15]2)=[O:5].[ClH:36]>CO.O1CCOCC1>[ClH:36].[Br:1][C:2]1[CH:21]=[CH:20][C:19]([CH2:22][N:23]2[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]2)=[CH:18][C:3]=1[C:4]([NH:6][CH2:7][C:8]12[CH2:9][CH:10]3[CH2:16][CH:14]([CH2:13][CH:12]([CH2:11]3)[CH2:17]1)[CH2:15]2)=[O:5]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 18381502HCID 18381502, compound

Product 1

HCID 131723695HCID 131723695, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

2-Bromo-5-(4-[{1,1-dimethylethyl}oxycarbonyl]-piperazin-1-yl)methyl-N-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-benzamide (Example 65b, 0.40 g) was dissolved in methanol (15 ml), and 4N HCl in dioxane (3 ml) added. The mixture was stirred at room temperature for 14 h. The solvent was removed under vacuum and the resulting solid was triturated with ether to afford the title compound as a white powder (0.23 g).

Workup

  1. customThe solvent was removed under vacuum
  2. customthe resulting solid was triturated with ether

Sources & evidence

ORD record
ord-3d1b76f63c8e48a98b540e5f0525fc9f
Source dataset
uspto-grants-2002_12
Patent number
US06492355B1

Reaction notes

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