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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2298108Generated: October 30, 2026

Hydrochloric Acid → HCID 131723705, compound

https://huagongshe.com/reaction/2298108

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantHCID 57215457HCID 57215457—
SolventMethanolHCID 887—
Solvent1,4-DioxaneHCID 31275—
ProductHCID 131723705HCID 131723705123.4%

Reaction Steps

To a solution of 4-[1-[4chloro-3-[[(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]carbonyl]phenyl]-1-hydroxyethyl]-1-piperidinecarboxylic acid, 1,1-dimethylethyl ester (0.07 g, Example 77a) in methanol (3 ml) was added 4N hydrochloric acid solution in dioxane (1 ml). After 14 h the solvents were removed under reduced pressure and the residue was triturated with diethyl ether to give the title compound as a white powder (0.038 g).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06492355B1
Source datasetuspto-grants-2002_12
ORD IDord-db4c3693858f453c8badeb9717dcab3c
Source noteuspto-grants-2002_12