Hydrochloric Acid → HCID 131723705, compound

HRID 2298108Notes

Reaction equation

HRID 2298108 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([CH:11]2[CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][CH2:12]2)([OH:10])[CH3:9])=[CH:4][C:3]=1[C:24]([NH:26][CH2:27][C:28]12[CH2:37][CH:32]3[CH2:33][CH:34]([CH2:36][CH:30]([CH2:31]3)[CH2:29]1)[CH2:35]2)=[O:25].Cl>CO.O1CCOCC1>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([OH:10])([CH:11]2[CH2:12][CH2:13][NH:14][CH2:15][CH2:16]2)[CH3:9])=[CH:4][C:3]=1[C:24]([NH:26][CH2:27][C:28]12[CH2:29][CH:30]3[CH2:31][CH:32]([CH2:33][CH:34]([CH2:36]3)[CH2:35]1)[CH2:37]2)=[O:25]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 57215457HCID 57215457, compound

Product 1

HCID 131723705HCID 131723705, compoundYield 123.4%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of 4-[1-[4chloro-3-[[(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]carbonyl]phenyl]-1-hydroxyethyl]-1-piperidinecarboxylic acid, 1,1-dimethylethyl ester (0.07 g, Example 77a) in methanol (3 ml) was added 4N hydrochloric acid solution in dioxane (1 ml). After 14 h the solvents were removed under reduced pressure and the residue was triturated with diethyl ether to give the title compound as a white powder (0.038 g).

Workup

  1. customAfter 14 h the solvents were removed under reduced pressure
  2. customthe residue was triturated with diethyl ether

Sources & evidence

ORD record
ord-db4c3693858f453c8badeb9717dcab3c
Source dataset
uspto-grants-2002_12
Patent number
US06492355B1

Reaction notes

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