1,4,5,6-Tetrahydropyrimidine → 2-Chloro-5-[(5,6-dihydro-1(4H)-pyrimidinyl)methyl]-N-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-benzamide

HRID 2298109Notes

Reaction equation

HRID 2298109 reaction equation
Br[CH2:2][C:3]1[CH:4]=[CH:5][C:6]([Cl:23])=[C:7]([CH:22]=1)[C:8]([NH:10][CH2:11][C:12]12[CH2:21][CH:16]3[CH2:17][CH:18]([CH2:20][CH:14]([CH2:15]3)[CH2:13]1)[CH2:19]2)=[O:9].[NH:24]1[CH2:29][CH2:28][CH2:27][N:26]=[CH:25]1>>[Cl:23][C:6]1[CH:5]=[CH:4][C:3]([CH2:2][N:26]2[CH2:27][CH2:28][CH2:29][N:24]=[CH:25]2)=[CH:22][C:7]=1[C:8]([NH:10][CH2:11][C:12]12[CH2:13][CH:14]3[CH2:15][CH:16]([CH2:17][CH:18]([CH2:20]3)[CH2:19]1)[CH2:21]2)=[O:9]

Participants

3

Reactant 2

HCID 1371051,4,5,6-TetrahydropyrimidineHCID 219000205-Bromomethyl-2chloro-N-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-benzamide

Product 1

HCID 183815672-Chloro-5-[(5,6-dihydro-1(4H)-pyrimidinyl)methyl]-N-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-benzamide

Procedure

Prepared according to the method described in Example 8 from 5-bromomethyl-2-chloro-N-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-benzamide (Example 8b,) and 1,4,5,6-tetrahydro-pyrimidine.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-fa75086b4fad47a2b337f9f232b0d628
Source dataset
uspto-grants-2002_12
Patent number
US06492355B1

Reaction notes

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