反应详情

N-(4-(2-ethyl-4-hydroxy-5-isopropylphenoxy)-3,5-dibromophenyl)oxamic acid methyl ester (50 mg, 0.01 mmol), was dissolved in acetone (2 ml). 1M NaOH (1 ml) was added and the solution was stirred for 1 hour, cooled in an ice bath, acidified with 1M HCl, concentrated, extracted with ethyl acetate, dried over MgSO4, filtered and evaporated to give 36 mg (74%) of N-(4-(2-ethyl-4-hydroxy-5-isopropylphenoxy)-3,5-dibromophenyl)oxamic acid. 1H NMR (CD3COCD3): d 10.24 (s, 1H), 8.33 (s, 2H), 6.77 (s, 1H), 6.12 (s, 1H), 3.16 (m, 1H), 2.74 (q, 2H), 1.27 (t, 3H), 1.04 (d, 6H).

1. temperaturecooled in an ice bath
2. concentrationconcentrated
3. extractionextracted with ethyl acetate
4. dry with materialdried over MgSO4
5. filtrationfiltered
6. customevaporated