Tetrahydrofuran → HCID 9864551, compound

HRID 2298275Notes

Reaction equation

HRID 2298275 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:9]2[C:10](=[O:24])[C:11]([CH3:23])([CH3:22])[O:12][C:13]=2[C:14]2[CH:19]=[CH:18][C:17](SC)=[CH:16][CH:15]=2)[CH:5]=[C:6]([F:8])[CH:7]=1.O[O:26][S:27]([O-:29])=O.[K+].[CH2:31]1COCC1>C(O)C.O>[F:1][C:2]1[CH:3]=[C:4]([C:9]2[C:10](=[O:24])[C:11]([CH3:23])([CH3:22])[O:12][C:13]=2[C:14]2[CH:19]=[CH:18][C:17]([S:27]([CH3:31])(=[O:29])=[O:26])=[CH:16][CH:15]=2)[CH:5]=[C:6]([F:8])[CH:7]=1

Participants

6

Reactant 3

HCID 8028TetrahydrofuranHCID 18385870HCID 18385870, compoundHCID 23707502Potassium hydroxy sulfite

Product 1

HCID 9864551HCID 9864551, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

Alternatively, 18 g of 4-(3,5-difluorophenyl)-2,2-dimethyl-5-{4-(methylthio)-phenyl}-3(2H)-furanone (Example 173) was reacted with 45 g of OXONE in 300 ml THF, 300 ml ethanol and 300 ml water according to a procedure similar to the alternative procedure of Example 4 to afford 19.5 g of 4-(3,5-difluorophenyl)-2,2-dimethyl-5-{4-(methylsulfonyl)phenyl}-3(2H)-furanone.

Sources & evidence

ORD record
ord-c67cb717cbc04f4a945b1c66fa8ef6ff
Source dataset
uspto-grants-2002_12
Patent number
US06492416B1

Reaction notes

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