反应详情

5.34 g of 4-hydroxy-4-methyl-1-{4-(methylthio)phenyl}-2-hexyn-1-one was dissolved in 200 ml ethanol, added dropwise 3 ml diethylamine diluted with 50 ml ethanol. The reaction solution was stirred at room temperature for 4 hours, and the solvent was removed in vacuo. The resulting residue was extracted with water and dichloromethane (100 ml×3). Concentration of the organic layer afforded crude 2-ethyl-2-methyl-5-{4-(methylthio)phenyl}-3(2H)-furanone, which was used in the next step without further purification.

1. customthe solvent was removed in vacuo
2. extractionThe resulting residue was extracted with water and dichloromethane (100 ml×3)