Hydrochloric Acid → HCID 69001190, compound

HRID 229836Notes

Reaction equation

HRID 229836 reaction equation
Cl.[CH3:2][O:3][C:4](=[O:38])[C@@H:5]([NH:10][C:11]([N:13]1[CH2:19][CH:18]([OH:20])[C@@H:17]([NH:21][C:22](=[O:36])[C@@H:23]([NH:28]C(OC(C)(C)C)=O)[CH2:24][CH:25]([CH3:27])[CH3:26])[CH2:16][CH2:15][C@H:14]1[CH3:37])=[O:12])[CH2:6][CH:7]([CH3:9])[CH3:8]>O1CCOCC1.CO>[CH3:2][O:3][C:4](=[O:38])[C@@H:5]([NH:10][C:11]([N:13]1[CH2:19][CH:18]([OH:20])[C@@H:17]([NH:21][C:22](=[O:36])[C@@H:23]([NH2:28])[CH2:24][CH:25]([CH3:26])[CH3:27])[CH2:16][CH2:15][C@H:14]1[CH3:37])=[O:12])[CH2:6][CH:7]([CH3:9])[CH3:8]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 69001166HCID 69001166, compound

Product 1

HCID 69001190HCID 69001190, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

4.0 M HCl in dioxane (8 ml) was added to a stirred solution (S)-2-({1-[(2R,5S)-5-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-2-methyl-6-hydroxy-azepan-1-yl]-methanoyl}-amino)-4-methyl-pentanoic acid methyl ester (490 mg, 0.93 mmol) in MeOH (8 ml). The reaction mixture was stirred for 2.5 h at RT, then was concentrated in vacuo by rotary evaporation and was used in the next reaction without further purification (430 mg).

Workup

  1. concentrationwas concentrated in vacuo by rotary evaporation
  2. customwas used in the next reaction without further purification (430 mg)

Sources & evidence

ORD record
ord-7e8140b4fa2b425ebacdb2b167b3cb48
Source dataset
uspto-grants-2009_07
Patent number
US07563784B2

Reaction notes

Loading…