Acetate → HCID 15389278, compound

HRID 2298438Notes

Reaction equation

HRID 2298438 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([CH:7]=[C:8]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:3][CH:2]=1.CC([O-])=O>C(O)C.[Pd]>[NH:1]1[CH2:2][CH2:3][CH:4]([CH:7]=[C:8]([C:9]([O:11][CH2:12][CH3:13])=[O:10])[C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH2:5][CH2:6]1

Participants

5

Reactant 2

HCID 175AcetateHCID 5307014HCID 5307014, compound

Product 1

HCID 15389278HCID 15389278, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of diethyl (4-pyridylmethylene)malonate [XXVIIIb] (97.6 g) in absolute ethanol (1 L) was hydrogenated in the presence of acetic acid glacial (35.5 g) and 10% Palladium on activated carbon catalyst (9.7 g) at 60° C. and 200 psi for 20 hours. The catalyst was filtered off and the resulting solution of the title compound in the form of acetic acid salt was used directly in the next step.

Workup

  1. filtrationThe catalyst was filtered off

Sources & evidence

ORD record
ord-44b5694bb4a24c35ba698b3e00e2f5e6
Source dataset
uspto-grants-2002_12
Patent number
US06492522B1

Reaction notes

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