Isopropyl iodide → 3-isopropoxynitrobenzene

Participants

Reaction Steps

3-nitrophenol (50.0 g, 360 mmol), isopropyl iodide (76.19 g, 450 mmol), and K2CO3 (60 g) were combined and heated at reflux under N2 overnight in acetone (400 mL). After solvent removal in vacuo, the residue was partitioned between EtOAc and H2O. The separated organic layer was washed with 1 N NaOH, brine, dried over Na2SO4, and concentrated in vacuo to provide 56 g (86%) of 3-isopropoxynitrobenzene as a clear yellow oil.

Provenance & Evidence