3-Bromopropionic acid → Tert-butyl 3-bromopropanoic Acid

HRID 2298504Notes

Reaction equation

HRID 2298504 reaction equation
[Br:1][CH2:2][CH2:3][C:4]([OH:6])=[O:5].BrCCCCCC(O[C:16]([CH3:19])([CH3:18])[CH3:17])=O>C=C(C)C>[C:16]([CH:3]([CH2:2][Br:1])[C:4]([OH:6])=[O:5])([CH3:19])([CH3:18])[CH3:17]

Participants

4

Reactant 2

HCID 115533-Bromopropionic acidHCID 11550568Tert-butyl 6-bromohexanoate

Product 1

HCID 18386960Tert-butyl 3-bromopropanoic AcidYield 36%

Reagents, catalysts & solvents 1

HCID 8255IsobutyleneSolvent

Procedure

3-Bromopropanoic acid (8.2 g, 53.6 mmol) and iso-butene (60 ml) were reacted by the same procedure as described in Example 1 for the preparation of tert-butyl 6-bromohexanoate and afforded the title material (4 g, 36%) as a colorless liquid.

Sources & evidence

ORD record
ord-a0314a9b9ca7423286f81dccf0377d9b
Source dataset
uspto-grants-2002_12
Patent number
US06492550B2

Reaction notes

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