HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl acetoacetate → Rac-5-(5-chloro-2-methoxy-4-methyl-phenyl)-1-[1,4]dioxan-2-ylmethyl-2-methyl-1h-pyrrole-3-carboxylic acid piperidin-1-ylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl acetoacetate | HCID 7757 | — |
| Reactant | 1-Aminopiperidine | HCID 16658 | — |
| Reactant | 2-Bromo-1-(5-chloro-2-methoxy-4-methylphenyl)ethanone | HCID 2756888 | — |
| Reactant | 1,4-Dioxan-2-ylmethanamine | HCID 3748064 | — |
| Product | Rac-5-(5-chloro-2-methoxy-4-methyl-phenyl)-1-[1,4]dioxan-2-ylmethyl-2-methyl-1h-pyrrole-3-carboxylic acid piperidin-1-ylamide | HCID 11590743 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 7, using 3-oxo-butyric acid methyl ester as compound of formula R, 2-bromo-1-(5-chloro-2-methoxy-4-methyl-phenyl)-ethanone (purchased from Oakwood) as compound of formula S, rac-1,4-dioxane-2-methanamine as R3—(CH2)m—NH2 and piperidine-1-ylamine as R1R2NH, MS (ISP) 462.2 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07563910B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-35626689a35c4dd09bc9fb92596f41a5 |
| Source note | uspto-grants-2009_07 |