2-Bromo-1-(3,5-dimethoxyphenyl)ethanone → HCID 86758665, compound

HRID 2298585Notes

Reaction equation

HRID 2298585 reaction equation
[NH2:1][C:2](=[S:13])[C:3]1[CH:4]=[C:5]([C:9]([O:11][CH3:12])=[S:10])[S:6][C:7]=1[CH3:8].Br[CH2:15][C:16]([C:18]1[CH:23]=[C:22]([O:24][CH3:25])[CH:21]=[C:20]([O:26][CH3:27])[CH:19]=1)=O>>[CH3:27][O:26][C:20]1[CH:19]=[C:18]([C:16]2[N:1]=[C:2]([C:3]3[CH:4]=[C:5]([C:9]([O:11][CH3:12])=[S:10])[S:6][C:7]=3[CH3:8])[S:13][CH:15]=2)[CH:23]=[C:22]([O:24][CH3:25])[CH:21]=1

Participants

3

Reactant 2

HCID 27569322-Bromo-1-(3,5-dimethoxyphenyl)ethanoneHCID 86583815Methyl 4-(aminothioxomethyl)-5-methylthiothiophene-2-carboxylate

Product 1

HCID 86758665HCID 86758665, compoundYield 27.8%

Procedure

100 mg (0.404 mmol) of methyl 4-(aminothioxomethyl)-5-methylthiothiophene-2-carboxylate (Maybridge Chemical Co. LTD., Cornwall, U.K.) was reacted with 2-bromo-3′,5′-dimethoxy acetophenone (0.444 mmol) in a manner similar to Example 22, step (a) to afford 44 mg (27% yield) of methyl 4-[4-(3,5-dimethoxyphenyl)(1,3-thiazol-2-yl)]-5-methylthiothiophene-2-carboxylate.

Sources & evidence

ORD record
ord-9cb06de0be104090924ed9c0a9a843a0
Source dataset
uspto-grants-2002_12
Patent number
US06492403B1

Reaction notes

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