2-Thiophenecarboxaldehyde → HCID 73430731, compound

HRID 2298698Notes

Reaction equation

HRID 2298698 reaction equation
[OH:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][C:10]([S:13]([OH:16])(=[O:15])=[O:14])=[CH:9][CH:8]=2)[N:5]=[C:4]([CH3:17])[CH:3]=1.[S:18]1[CH:22]=[CH:21][CH:20]=[C:19]1[CH:23]=O.C([O-])(=O)C.[NH4+:29]>C(O)C>[CH3:17][C:4]1[C:3](=[CH:23][C:19]2[S:18][CH:22]=[CH:21][CH:20]=2)[C:2](=[O:1])[N:6]([C:7]2[CH:8]=[CH:9][C:10]([S:13]([O-:16])(=[O:15])=[O:14])=[CH:11][CH:12]=2)[N:5]=1.[NH4+:29]

Participants

5

Reactant 3

HCID 73642-ThiophenecarboxaldehydeHCID 517165Ammonium AcetateHCID 178429269HCID 178429269, compound

Product 1

HCID 73430731HCID 73430731, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

12.75 g of 5-hydroxy-3-methyl-1-(4-sulfophenyl)-1H-pyrazole, 6.2 g of thiophene-2-carboxaldehyde and 3.85 g of ammonium acetate in 100 mL of ethanol were heated at 80° C. After 4 hours, the mixture was cooled and filtered. The crude product was allowed to reflux in 250 mL of methanol for 30 min and the mixture was then cooled and filtered.

Workup

  1. temperaturethe mixture was cooled
  2. filtrationfiltered
  3. temperatureto reflux in 250 mL of methanol for 30 min
  4. temperaturethe mixture was then cooled
  5. filtrationfiltered

Sources & evidence

ORD record
ord-1c6a304c91fc4d93b93911b8e13de6d3
Source dataset
uspto-grants-2002_12
Patent number
US06494923B2

Reaction notes

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