Sodium Hydroxide → 4-(2-Methoxy-6H-pyrido[2',3':4,5]pyrrolo[2,1-a]isoindol-11-yl)-butanoic acid

HRID 2298758Notes

Reaction equation

HRID 2298758 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[N:10]3[CH2:11][C:12]4[C:17]([C:9]3=[C:8]([CH:18]=[CH:19][CH2:20][C:21]([O:23]CC)=[O:22])[C:7]=2[N:26]=1)=[CH:16][CH:15]=[CH:14][CH:13]=4.[OH-].[Na+]>C(O)C>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[N:10]3[CH2:11][C:12]4[C:17]([C:9]3=[C:8]([CH2:18][CH2:19][CH2:20][C:21]([OH:23])=[O:22])[C:7]=2[N:26]=1)=[CH:16][CH:15]=[CH:14][CH:13]=4

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 69419312Ethyl 4-(2-methoxy-6H-pyrido[2',3':4,5]pyrrolo[2,1-a]isoindol-11-yl)-3-butenoate

Product 1

HCID 187582074-(2-Methoxy-6H-pyrido[2',3':4,5]pyrrolo[2,1-a]isoindol-11-yl)-butanoic acid

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The ester obtained in Step A is placed in 150 ml of ethanol in the presence of 40 ml of 2N sodium hydroxide solution. The title acid is isolated after stirring at room temperature and then refluxing.

Sources & evidence

ORD record
ord-8baf6058e05444179f6f6d038d2ec189
Source dataset
uspto-grants-2002_12
Patent number
US06495543B1

Reaction notes

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