反应详情

温度

60 °C

A solution of methyl 2-methoxy-4-(2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)carbonylbenzoate (450 mg) in a mixture of methanol (15 ml) and 1 N aqueous sodium hydroxide (3 ml) was stirred at 60° C. for 2 hours and the solution was cooled to room temperature. The solution was adjusted to pH 2-3 with 1N hydrochloric acid and extracted with chloroform. The organic layer was washed with water and brine and dried over magnesium sulfate. The solvent was evaporated in vacuo and the residue was solidified with ether to give 2-methoxy-4-(2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)carbonylbenzoic acid (410 mg).

1. temperaturethe solution was cooled to room temperature
2. extractionextracted with chloroform
3. washThe organic layer was washed with water and brine
4. dry with materialdried over magnesium sulfate
5. customThe solvent was evaporated in vacuo