Hydrochloric Acid → HCID 18378643, compound

HRID 2298805Notes

Reaction equation

HRID 2298805 reaction equation
[NH2:1][CH2:2][C:3]1[NH:7][C:6]2[CH:8]=[CH:9][CH:10]=[C:11]([NH:12][C:13](=[O:35])[C:14]3[CH:19]=[CH:18][C:17]([C:20]([N:22]4[C:28]5[CH:29]=[CH:30][CH:31]=[CH:32][C:27]=5[CH2:26][CH2:25][CH2:24][CH2:23]4)=[O:21])=[CH:16][C:15]=3[O:33][CH3:34])[C:5]=2[N:4]=1.[ClH:36]>O>[ClH:36].[ClH:36].[NH2:1][CH2:2][C:3]1[NH:7][C:6]2[CH:8]=[CH:9][CH:10]=[C:11]([NH:12][C:13](=[O:35])[C:14]3[CH:19]=[CH:18][C:17]([C:20]([N:22]4[C:28]5[CH:29]=[CH:30][CH:31]=[CH:32][C:27]=5[CH2:26][CH2:25][CH2:24][CH2:23]4)=[O:21])=[CH:16][C:15]=3[O:33][CH3:34])[C:5]=2[N:4]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 9912514HCID 9912514, compound

Product 1

HCID 18378643HCID 18378643, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

N-(2-Aminomethyl-1H-benzimidazol-4-yl)-2-methoxy-4-(2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)carbonylbenzamide (150 mg) was dissolved in a mixture of 1N hydrochloric acid (0.7 ml) and water (5 ml), and the solution was lyophilized to give N-(2-aminomethyl-1H-benzimidazol-4-yl)-2-methoxy-4-(2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)carbonylbenzamide dihydrochloride (132 mg).

Sources & evidence

ORD record
ord-b9363e59db4b4a0ab51e2f325612649d
Source dataset
uspto-grants-2002_12
Patent number
US06495542B1

Reaction notes

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