反应详情

温度

50 °C

A mixture of 2-chloro-4-nitro-1H-benzimidazole (300 mg) and morpholine (1 ml) was stirred at 50° C. for 8 hours. The reaction mixture was poured into saturated aqueous sodium hydrogencarbonate solution and extracted with chloroform. The organic layer was washed with brine, and dried over magnesium sulfate. The solvent was evaporated in vacuo. The residue was washed with isopropyl ether and collected by vacuum filtration to give 2-(morpholin-4-yl)-4-nitro-1H-benzimidazole (288 mg).

1. extractionextracted with chloroform
2. washThe organic layer was washed with brine
3. dry with materialdried over magnesium sulfate
4. customThe solvent was evaporated in vacuo
5. washThe residue was washed with isopropyl ether
6. filtrationcollected by vacuum filtration