Lithium Hydroxide → (2S)-1-(6-isobutyl-1,3-benzoxazol-2-yl)-2-piperidinecarboxylic acid

HRID 2298864Notes

Reaction equation

HRID 2298864 reaction equation
[CH2:1]([C:5]1[CH:23]=[CH:22][C:8]2[N:9]=[C:10]([N:12]3[CH2:17][CH2:16][CH2:15][CH2:14][C@H:13]3[C:18]([O:20]C)=[O:19])[O:11][C:7]=2[CH:6]=1)[CH:2]([CH3:4])[CH3:3].[OH-].[Li+]>>[CH2:1]([C:5]1[CH:23]=[CH:22][C:8]2[N:9]=[C:10]([N:12]3[CH2:17][CH2:16][CH2:15][CH2:14][C@H:13]3[C:18]([OH:20])=[O:19])[O:11][C:7]=2[CH:6]=1)[CH:2]([CH3:4])[CH3:3]

Participants

3

Reactant 2

HCID 3939Lithium HydroxideHCID 9839924methyl (2S)-1-(6-isobutyl-1,3-benzoxazol-2-yl)-2-piperidinecarboxylate

Product 1

HCID 18340163(2S)-1-(6-isobutyl-1,3-benzoxazol-2-yl)-2-piperidinecarboxylic acid

Procedure

The title compound was prepared by a similar method to Preparation 3 from methyl (2S)-1-(6-isobutyl-1,3-benzoxazol-2-yl)-2-piperidinecarboxylate [see Preparation 41] and 1N aqueous lithium hydroxide solution, to afford (2S)-1-(6-isobutyl-1,3-benzoxazol-2-yl)-2-piperidinecarboxylic acid as a foam.

Sources & evidence

ORD record
ord-7f807f874b524bfb99b05451c687ff8f
Source dataset
uspto-grants-2002_12
Patent number
US06495549B1

Reaction notes

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