HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-[4-(3-Chloro-4-methoxybenzyl-amino)benzothieno[2,3-d]pyrimidin-2-yl]propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Methyl 3-[4-(3-chloro-4-methoxybenzylamino)-benzothieno[2,3-d]pyrimidin-2-yl]propionate | HCID 10983074 | — |
| Solvent | 2-Methoxyethanol | HCID 8019 | — |
| Product | 3-[4-(3-Chloro-4-methoxybenzyl-amino)benzothieno[2,3-d]pyrimidin-2-yl]propionic acid | HCID 9910420 | — |
Reaction Steps
Methyl 3-[4-(3-chloro-4-methoxybenzylamino)-benzothieno[2,3-d]pyrimidin-2-yl]propionate is dissolved in ethylene glycol monomethyl ether and; after addition of 32% strength NaOH, stirred at 110° for 5 hours. 20% strength HCl is added, and the mixture is then extracted with dichloromethane. Addition of petroleum ether affords 3-[4-(3-chloro-4-methoxybenzylamino)benzothieno[2,3-d]pyrimidin-2-yl]propionic acid, m.p. 218°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06495557B1 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-09eea41f05c54019885f6687961d1d68 |
| Source note | uspto-grants-2002_12 |