反应详情

Methyl 3-[4-(3-chloro-4-methoxybenzylamino)-benzothieno[2,3-d]pyrimidin-2-yl]propionate is dissolved in ethylene glycol monomethyl ether and; after addition of 32% strength NaOH, stirred at 110° for 5 hours. 20% strength HCl is added, and the mixture is then extracted with dichloromethane. Addition of petroleum ether affords 3-[4-(3-chloro-4-methoxybenzylamino)benzothieno[2,3-d]pyrimidin-2-yl]propionic acid, m.p. 218°.

1. extractionthe mixture is then extracted with dichloromethane
2. additionAddition of petroleum ether