Methanol → HCID 86596485, compound

HRID 229888Notes

Reaction equation

[CH3:1][OH:2].CC1C=CC([S:10]([OH:13])(=[O:12])=[O:11])=CC=1.[CH:14]([Cl:17])([Cl:16])[Cl:15]>>[CH:14]([Cl:17])([Cl:16])[Cl:15].[CH3:1][OH:2].[S:10](=[O:11])(=[O:2])([OH:12])[OH:13]

Participants

Reactant 3

HCID 887Methanol

HCID 6101p-Toluenesulfonic acid

HCID 6212Chloroform

Product 1

HCID 86596485HCID 86596485, compound

Procedure

A colorless solid (yield: 90.9%) was obtained through reaction conducted as in example 54 except that the reactants were replaced by the compound (123) prepared in example 23 (0.5 g), methanol (42.7 mL), chloroform (42.7 mL) and p-toluene sulfonate (4.43 g), the reaction temperature was lowered to room temperature and the reaction time was extended to 72 hours. 1H-NMR data showed that the product consisted of a compound (144) and the compound (123) (content of compound (144): 89.0 mol %).

Workup

customwas lowered to room temperature

Sources & evidence

ORD record: ord-475fbd15533f42148e816e7fdc6d3311
Source dataset: uspto-grants-2009_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07563917B2

Reaction notes

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