Acetic Anhydride → HCID 70153727, compound

HRID 2299027Notes

Reaction equation

HRID 2299027 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([N:23]2[CH2:27][C@H:26]([CH2:28][NH:29][C:30](=[O:32])[CH3:31])[O:25][C:24]2=[O:33])[CH:5]=[CH:6][C:7]=1[N:8]1[CH:12]=[C:11]([C:13]([NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([NH2:22])[N:17]=2)=[O:14])[N:10]=[CH:9]1.[C:34](OC(=O)C)(=[O:36])[CH3:35]>N1C=CC=CC=1>[F:1][C:2]1[CH:3]=[C:4]([N:23]2[CH2:27][C@H:26]([CH2:28][NH:29][C:30](=[O:32])[CH3:31])[O:25][C:24]2=[O:33])[CH:5]=[CH:6][C:7]=1[N:8]1[CH:12]=[C:11]([C:13]([NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([NH:22][C:34](=[O:36])[CH3:35])[N:17]=2)=[O:14])[N:10]=[CH:9]1

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 57037837HCID 57037837, compound

Product 1

HCID 70153727HCID 70153727, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

N-[(5S)-3-(3-Fluoro-4-(4-(6-aminopyridin-2-ylaminocarbonyl)imidazol-1-yl)phenyl)-2-oxooxazolidin-5-ylmethyl]acetamide (70 mg, 0.15 mM) was dissolved in pyridine (3 ml) and treated with acetic anhydride (0.5 ml). After standing 60 hours at ambient temperature, solvent was evaporated, and the residue triturated with water (10 ml). Filtration gave the title product (47 mg).

Workup

  1. customsolvent was evaporated
  2. customthe residue triturated with water (10 ml)
  3. filtrationFiltration

Sources & evidence

ORD record
ord-635c0939340e44699a2048bf2c1566de
Source dataset
uspto-grants-2002_12
Patent number
US06495551B1

Reaction notes

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