p-Toluenesulfonic acid → n-(1-(1h-1,2,3-Benzotriazol-1-yl)-2,2-dimethylpropyl)-4-chlorobenzamide

HRID 2299043Notes

Reaction equation

[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH2:8])=[O:7])=[CH:4][CH:3]=1.[CH3:11][C:12]([CH:15]=O)([CH3:14])[CH3:13].[NH:17]1[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=2[N:19]=[N:18]1.C1(C)C=CC(S(O)(=O)=O)=CC=1>>[N:17]1([CH:15]([NH:8][C:6](=[O:7])[C:5]2[CH:9]=[CH:10][C:2]([Cl:1])=[CH:3][CH:4]=2)[C:12]([CH3:13])([CH3:14])[CH3:11])[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=2[N:19]=[N:18]1

Participants

Reactant 4

HCID 6101p-Toluenesulfonic acid

HCID 120844-Chlorobenzamide

HCID 12417Pivalaldehyde

HCID 178418385HCID 178418385, compound

Product 1

HCID 18770523n-(1-(1h-1,2,3-Benzotriazol-1-yl)-2,2-dimethylpropyl)-4-chlorobenzamide

Procedure

A suspension of 4-chlorobenzamide, pivaldehyde, benzotriazole, and p-toluenesulfonic acid was processed as described in Example 1C to provide the title compound.

Sources & evidence

ORD record: ord-78a0c472a33f4161ae363701f02e0fa0
Source dataset: uspto-grants-2002_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06495576B2

Reaction notes

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