p-Toluenesulfonic acid → N-[1-(1H-1,2,3-benzotriazol-1-yl)-2,2-dichloropropyl]4-chlorobenzamide

HRID 2299061Notes

Reaction equation

HRID 2299061 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH2:8])=[O:7])=[CH:4][CH:3]=1.[Cl:11][C:12]([Cl:16])([CH3:15])[CH:13]=O.[NH:17]1[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=2[N:19]=[N:18]1.C1(C)C=CC(S(O)(=O)=O)=CC=1>>[N:17]1([CH:13]([NH:8][C:6](=[O:7])[C:5]2[CH:9]=[CH:10][C:2]([Cl:1])=[CH:3][CH:4]=2)[C:12]([Cl:16])([Cl:11])[CH3:15])[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=2[N:19]=[N:18]1

Participants

5

Reactant 4

HCID 6101p-Toluenesulfonic acidHCID 120844-ChlorobenzamideHCID 109754962,2-DichloropropanalHCID 178418385HCID 178418385, compound

Product 1

HCID 18770573N-[1-(1H-1,2,3-benzotriazol-1-yl)-2,2-dichloropropyl]4-chlorobenzamide

Procedure

4-Chlorobenzamide, the product from Example 24A, benzotriazole, and p-toluenesulfonic acid were processed as described in Example 1C to provide the title compound.

Sources & evidence

ORD record
ord-52beb038eed142ab944c9d601a0752e1
Source dataset
uspto-grants-2002_12
Patent number
US06495576B2

Reaction notes

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