Diethyl squarate → 3-(5-Bromo-6-fluoro-pyridin-3-ylamino)-4-ethoxy-cyclobut-3-ene-1,2-dione

HRID 2299066Notes

Reaction equation

HRID 2299066 reaction equation
[F:1][C:2]1[C:7]([Br:8])=[CH:6][C:5]([NH2:9])=[CH:4][N:3]=1.[CH2:10]([O:12][C:13]1[C:14](=O)[C:15](=[O:20])[C:16]=1[O:17]CC)[CH3:11]>C(O)C>[Br:8][C:7]1[CH:6]=[C:5]([NH:9][C:14]2[C:15](=[O:20])[C:16](=[O:17])[C:13]=2[O:12][CH2:10][CH3:11])[CH:4]=[N:3][C:2]=1[F:1]

Participants

4

Reactant 2

HCID 123228Diethyl squarateHCID 183797255-Bromo-6-fluoropyridin-3-amine

Product 1

HCID 183796983-(5-Bromo-6-fluoro-pyridin-3-ylamino)-4-ethoxy-cyclobut-3-ene-1,2-dione

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 2-fluoro-3-bromo-5-aminopyridine and 3,4-diethoxy-3-cyclobutene-1,2-dione in ethanol was processed as described in Example 1A to provide the title compound.

Sources & evidence

ORD record
ord-930ace022d424c21977e644259830317
Source dataset
uspto-grants-2002_12
Patent number
US06495576B2

Reaction notes

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