p-Toluenesulfonic acid → HCID 18770642, compound

HRID 2299073Notes

Reaction equation

HRID 2299073 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH2:8])=[O:7])=[CH:4][C:3]=1[C:11]([F:14])([F:13])[F:12].[CH3:15][C:16]([CH:19]=O)([CH3:18])[CH3:17].[NH:21]1[C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=2[N:23]=[N:22]1.C1(C)C=CC(S(O)(=O)=O)=CC=1>>[N:21]1([CH:19]([NH:8][C:6](=[O:7])[C:5]2[CH:9]=[CH:10][C:2]([F:1])=[C:3]([C:11]([F:12])([F:13])[F:14])[CH:4]=2)[C:16]([CH3:17])([CH3:18])[CH3:15])[C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=2[N:23]=[N:22]1

Participants

5

Reactant 4

HCID 6101p-Toluenesulfonic acidHCID 12417PivalaldehydeHCID 1442544-Fluoro-3-(trifluoromethyl)benzamideHCID 178418385HCID 178418385, compound

Product 1

HCID 18770642HCID 18770642, compound

Procedure

A suspension of 4-fluoro-3-(trifluoromethyl)benzamide, pivaldehyde, benzotriazole, and p-toluenesulfonic acid was processed as in Example 1C to provide the title compound.

Sources & evidence

ORD record
ord-6eadf9e28a1c48618608aaa1a772c620
Source dataset
uspto-grants-2002_12
Patent number
US06495576B2

Reaction notes

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