p-Toluenesulfonic acid → HCID 86758706, compound

HRID 2299077Notes

Reaction equation

HRID 2299077 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([F:11])[CH:10]=1)[C:5]([NH2:7])=[O:6].[Cl:12][C:13]([Cl:17])([CH3:16])[CH:14]=O.[NH:18]1[C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=2[N:20]=[N:19]1.C1(C)C=CC(S(O)(=O)=O)=CC=1>>[N:18]1([CH2:14][C:13]([Cl:17])([Cl:12])[CH2:16][C:4]2([CH:3]=[C:2]([F:1])[CH:10]=[C:9]([F:11])[CH2:8]2)[C:5]([NH2:7])=[O:6])[C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=2[N:20]=[N:19]1

Participants

5

Reactant 4

HCID 6101p-Toluenesulfonic acidHCID 27369103,5-DifluorobenzamideHCID 109754962,2-DichloropropanalHCID 178418385HCID 178418385, compound

Product 1

HCID 86758706HCID 86758706, compound

Procedure

3,5-Difluorobenzamide, the product from Example 24A, benzotriazole, and p-toluenesulfonic acid were processed as described in Example 1C to provide the title compound.

Sources & evidence

ORD record
ord-6a02af6be6654ecb8e13a8ac13a2ddad
Source dataset
uspto-grants-2002_12
Patent number
US06495576B2

Reaction notes

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