p-Toluenesulfonic acid → HCID 18379720, compound

HRID 2299085Notes

Reaction equation

[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([NH2:8])=[O:7].[CH3:9][C:10]([CH:13]=O)([CH3:12])[CH3:11].[NH:15]1[C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=2[N:17]=[N:16]1.C1(C)C=CC(S(O)(=O)=O)=CC=1>>[N:15]1([CH:13]([NH:8][C:6]([C:2]2[S:1][CH:5]=[CH:4][CH:3]=2)=[O:7])[C:10]([CH3:11])([CH3:12])[CH3:9])[C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=2[N:17]=[N:16]1

Participants

Reactant 4

HCID 6101p-Toluenesulfonic acid

HCID 12417Pivalaldehyde

HCID 220632-Thiophenecarboxamide

HCID 178418385HCID 178418385, compound

Product 1

HCID 18379720HCID 18379720, compound

Procedure

A suspension of thiophene-2-carboxamide, pivaldehyde, benzotriazole, and p-toluenesulfonic acid was processed as in Example 1C to provide the title compound.

Sources & evidence

ORD record: ord-a1eb0b36fc174999aa8b4a98703ec730
Source dataset: uspto-grants-2002_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06495576B2

Reaction notes

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