p-Toluenesulfonic acid → N-[1-(1H-1,2,3-benzotriazol-1-yl)-2,2-dimethyl-3-phenylpropyl]-3-phenylpropionamide

HRID 2299095Notes

Reaction equation

HRID 2299095 reaction equation
[C:1]1([CH2:7][CH2:8][C:9]([NH2:11])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH:12]1[C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=2[N:14]=[N:13]1.[C:21]1([CH3:31])[CH:26]=[CH:25][C:24](S(O)(=O)=O)=[CH:23][CH:22]=1>>[N:12]1([CH:2]([NH:11][C:9](=[O:10])[CH2:8][CH2:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[C:1]([CH3:7])([CH3:6])[CH2:31][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=2[N:14]=[N:13]1

Participants

4

Reactant 3

HCID 6101p-Toluenesulfonic acidHCID 76253-PhenylpropanamideHCID 178418385HCID 178418385, compound

Product 1

HCID 18379747N-[1-(1H-1,2,3-benzotriazol-1-yl)-2,2-dimethyl-3-phenylpropyl]-3-phenylpropionamide

Procedure

A suspension of 3-(phenyl)propionamide, the product from Example 18A, benzotriazole, and p-toluenesulfonic acid was processed as described in Example 1C to provide the title compound.

Sources & evidence

ORD record
ord-2f262de64c0f49148d60d4051f87c526
Source dataset
uspto-grants-2002_12
Patent number
US06495576B2

Reaction notes

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