Sodium Hydroxide → Ibandronate Sodium Anhydrous

HRID 229911Notes

Reaction equation

HRID 229911 reaction equation
[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][N:6]([CH2:8][CH2:9][C:10]([P:16]([OH:19])([OH:18])=[O:17])([P:12]([OH:15])([OH:14])=[O:13])[OH:11])[CH3:7].[OH-].[Na+:21]>C(O)C>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][N:6]([CH2:8][CH2:9][C:10]([P:16]([O-:19])([OH:18])=[O:17])([P:12]([OH:15])([OH:14])=[O:13])[OH:11])[CH3:7].[Na+:21]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 60852Ibandronate

Product 1

HCID 23670359Ibandronate Sodium AnhydrousYield 102.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of amorphous ibandronic acid (5 g) in ethanol (50 ml) was stirred at room temperature. Aqueous sodium hydroxide (0.63 g, 12.5 ml) was added, and the reaction mixture was stirred at room temperature for an additional 2 hours. The precipitate was isolated by vacuum filtration, washed with ethanol (50 ml), and dried in a vacuum oven at 50° C. for 24 hours to obtain 5.5 g of ibandronate sodium crystal form Q5.

Workup

  1. customThe precipitate was isolated by vacuum filtration
  2. washwashed with ethanol (50 ml)
  3. customdried in a vacuum oven at 50° C. for 24 hours

Sources & evidence

ORD record
ord-cb180e4b94eb4e05a62bd4aad92a8458
Source dataset
uspto-grants-2009_07
Patent number
US07563918B2

Reaction notes

Loading…