Sodium Hydroxide → Ibandronate Sodium Anhydrous

Participants

Reaction Steps

A solution of amorphous ibandronic acid (5 g) in ethanol (50 ml) was stirred at room temperature. Aqueous sodium hydroxide (0.63 g, 12.5 ml) was added, and the reaction mixture was stirred at room temperature for an additional 2 hours. The precipitate was isolated by vacuum filtration, washed with ethanol (50 ml), and dried in a vacuum oven at 50° C. for 24 hours to obtain 5.5 g of ibandronate sodium crystal form Q5.

Provenance & Evidence