Ammonia → HCID 178507337, compound
Reaction equation
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]2[N:6]=[CH:7][NH:8][C:4]=2[CH:3]=1.[Br:11]Br.N>>[Br:11][C:3]1[C:4]2[NH:8][CH:7]=[N:6][C:5]=2[CH:9]=[CH:10][C:2]=1[NH2:1]Participants
4
Conditions
- Temperature
- 25 °C
Procedure
To a solution of 5-aminobenzimidazole (3.3 g, 2.3 mmol) in 30 ml of ACOH was added bromine (0.055 ml, 1.1 mmol) in a portion and resulting reaction mixture was stirred for 0.5 h at 25° C. Reaction mixture was concentrated in vacuo, yielding a dark brown solid which was subjected to silica gel column chromatography (NH3 saturated 10% MeOH/EtOAc) to yield 0.22 g (0.97 mmol, 42%) of the desired product.
Workup
- customresulting
- customreaction mixture
- customReaction mixture
- concentrationwas concentrated in vacuo
- customyielding a dark brown solid which
Sources & evidence
- ORD record
- ord-57fc0bfeeecd467e8445240c0436422a
- Source dataset
- uspto-grants-2002_12
- Patent number
- US06495583B1
Reaction notes
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