Ammonia → HCID 178507337, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 5-aminobenzimidazole (3.3 g, 2.3 mmol) in 30 ml of ACOH was added bromine (0.055 ml, 1.1 mmol) in a portion and resulting reaction mixture was stirred for 0.5 h at 25° C. Reaction mixture was concentrated in vacuo, yielding a dark brown solid which was subjected to silica gel column chromatography (NH3 saturated 10% MeOH/EtOAc) to yield 0.22 g (0.97 mmol, 42%) of the desired product.

Provenance & Evidence