Sodium Hydroxide → Ibandronate Sodium Anhydrous

HRID 229912Notes

Reaction equation

HRID 229912 reaction equation
[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][N:6]([CH2:8][CH2:9][C:10]([P:16]([OH:19])([OH:18])=[O:17])([P:12]([OH:15])([OH:14])=[O:13])[OH:11])[CH3:7].[OH-].[Na+:21]>CO>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][N:6]([CH2:8][CH2:9][C:10]([P:16]([O-:19])([OH:18])=[O:17])([P:12]([OH:15])([OH:14])=[O:13])[OH:11])[CH3:7].[Na+:21]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 60852Ibandronate

Product 1

HCID 23670359Ibandronate Sodium AnhydrousYield 101%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of amorphous ibandronic acid (5 g) in methanol (100 ml) was stirred at room temperature. Solid sodium hydroxide (0.63 g) was added. The obtained precipitate was stirred at room temperature for an additional 22 hours. The precipitate was isolated by vacuum filtration, washed with methanol (30 ml), and dried in a vacuum oven at 50° C. for 24 hours to obtain 5.4 g of ibandronate sodium crystal form Q5.

Workup

  1. customThe precipitate was isolated by vacuum filtration
  2. washwashed with methanol (30 ml)
  3. customdried in a vacuum oven at 50° C. for 24 hours

Sources & evidence

ORD record
ord-458cb3f09fb346aba693c32a02cae9d9
Source dataset
uspto-grants-2009_07
Patent number
US07563918B2

Reaction notes

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