Sodium Hydroxide → Ibandronate Sodium Anhydrous

Participants

Reaction Steps

A solution of amorphous ibandronic acid (5 g) in methanol (100 ml) was stirred at room temperature. Solid sodium hydroxide (0.63 g) was added. The obtained precipitate was stirred at room temperature for an additional 22 hours. The precipitate was isolated by vacuum filtration, washed with methanol (30 ml), and dried in a vacuum oven at 50° C. for 24 hours to obtain 5.4 g of ibandronate sodium crystal form Q5.

Provenance & Evidence