HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 3-Cyclohexylmethyl-4-bromo-5-aminobenzimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 3-Cyclohexylmethyl-5-aminobenzimidazole | HCID 18379826 | — |
| Reactant | Chloroform methanol | HCID 21584188 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 3-Cyclohexylmethyl-4-bromo-5-aminobenzimidazole | HCID 18379827 | 48% |
Reaction Steps
To a solution of 3-cyclohexylmethyl-5-aminobenzimidazole (2.0 g, 8.7 mmol) in 40 ml of AcOH was added solution of Br2 in AcOH until it produces a precipitation. The reaction mixture was concentrated in vacuo to provide a brown solid which was subjected to column chromatography (5% NH3 sat'd MeOH/CHCl3) to provide 1.2 g (3.8 mmol, 48%) of the product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06495583B1 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-265df3b086104a628baec8e06f80e2d0 |
| Source note | uspto-grants-2002_12 |