反应详情

26.00 g (102.0 mmol) of 2-bromo-1-(3-methylbut-2-enylthio)benzene, 130 ml of toluene and 23.20 g (122.0 mmol) of para-toluenesulphonic acid are introduced into a three-necked flask. The reaction mixture is heated at reflux for four hours and is evaporated to dryness. The residue is taken up in an aqueous sodium hydrogencarbonate solution and extracted with ethyl acetate and the organic phase is separated by settling, dried over magnesium sulphate and evaporated. The residue obtained is purified by chromatography on a silica column eluted with heptane. 20.00 g (76%) of the expected compound are collected in the form of an orangey oil.

1. temperatureThe reaction mixture is heated
2. temperatureat reflux for four hours
3. customis evaporated to dryness
4. extractionextracted with ethyl acetate
5. customthe organic phase is separated
6. dry with materialdried over magnesium sulphate
7. customevaporated
8. customThe residue obtained
9. customis purified by chromatography on a silica column
10. washeluted with heptane
11. custom20.00 g (76%) of the expected compound are collected in the form of an orangey oil