Ammonia → L-Aspartic Acid

HRID 2299237Notes

Reaction equation

HRID 2299237 reaction equation
[OH-].[NH4+:2].C1(=O)OC(=O)C=C1.[C:10]([OH:17])(=[O:16])/[CH:11]=[CH:12]\[C:13]([OH:15])=[O:14].N>O>[NH2:2][C@H:11]([C:10]([OH:17])=[O:16])[CH2:12][C:13]([OH:15])=[O:14]

Participants

6

Reactant 4

HCID 222AmmoniaHCID 7923Maleic AnhydrideHCID 14923Ammonium HydroxideHCID 444266Maleic Acid2×

Product 1

HCID 5960L-Aspartic Acid

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

In a 250 ml reagent bottle, an amount of 69 ml (0.11 mole) of a 10% solution of concentrated ammonium hydroxide (15.9 M) was slowly added with smooth stirring to 9.8 g (0.1 mole) of maleic anhydride in 18 ml (1 mole) of water at 60° C. The bottle was capped and the solution allowed to react for 2 hours. The anhydride converted to maleic acid in the presence of the water, and the ammonia added across the double bond of maleic acid to form aspartic acid.

Workup

  1. customThe bottle was capped
  2. customto react for 2 hours

Sources & evidence

ORD record
ord-5b1627ba9880457e864938ed3c99e499
Source dataset
uspto-grants-2002_12
Patent number
US06495658B2

Reaction notes

Loading…